Search results for "SARS-CoV-2-S antibodies"

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B and T cell immune responses elicited by the Comirnaty® COVID-19 vaccine in nursing home residents

2021

Objectives The immunogenicity of the Comirnaty® COVID-19 vaccine is understudied in elderly people with comorbidities. SARS-CoV-2-S-targeted antibody and T cell responses following full vaccination were assessed in nursing home residents. Methods Sixty nursing home residents (44 female; age, 53-100 years), of whom 10 had previously been diagnosed of COVID-19, and 18 healthy controls (15 female; age, 27-54 years) were recruited. Pre- and post-vaccination blood specimens were available for quantitation of total antibodies binding SARS-CoV-2 S protein and enumeration of SARS-CoV-2-S-reactive IFN-γ CD4+ and CD8+ T cells by flow cytometry. Results The seroconversion rate in presumably SARS-CoV-2…

AdultMale0301 basic medicineMicrobiology (medical)COVID-19 VaccinesSARS-CoV-2-S antibodiesT-LymphocytesT cell030106 microbiologyNursing home residentsAntibodies ViralFlow cytometryInterferon-gamma03 medical and health sciences0302 clinical medicineImmune systemComirnaty®COVID-19 vaccinemedicineHumans030212 general & internal medicineSeroconversionAgedAged 80 and overB-Lymphocytesbiologymedicine.diagnostic_testbusiness.industrySARS-CoV-2ImmunogenicityImmunityCOVID-19General MedicineMiddle AgedNursing HomesVaccinationInfectious Diseasesmedicine.anatomical_structureSARS-CoV-2-S T cellsSpike Glycoprotein CoronavirusImmunologybiology.proteinFemaleOriginal ArticleAntibodybusinessCD8Clinical Microbiology and Infection
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Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents

2022

6 páginas, 2 figuras, 3 tablas. Se puede acceder al texto completo de este artículo desde PubMedCentral: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490129 . Los datos de investigación utilizados en el mismo, se encuentran disponibles en: https://doi.org/10.1016/j.cmi.2021.09.031.

MaleMicrobiology (medical)medicine.medical_specialtyCOVID-19 VaccinesSARS-CoV-2-S antibodiesFingerstickSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Nursing home residentsCD8-Positive T-LymphocytesAntibodies ViralImmune systemComirnaty®COVID-19 vaccineInternal medicinemedicineHumansProspective StudiesProspective cohort studyAgedAged 80 and overVenipuncturebiologybusiness.industrySARS-CoV-2COVID-19General MedicineNursing HomesVaccinationInfectious Diseasesbiology.proteinFemaleOriginal ArticleAntibodybusinessCD8
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